Before you buy Reglan online
What It Does?
Reglan (Metoclopramide) is a specific blocker of dopamine and serotonin receptors.
The drug has antiemetic effect, soothes hiccup and, in addition, has a regulating effect on the gastrointestinal tract. Tone and motor activity of the digestive system is enhanced. Gastric secretion is unchanged. There are indications that the drug promotes healing of ulcers of the stomach and duodenum.
Reglan is used as an antiemetic for nausea, vomiting associated with anesthesia, radiotherapy, side effects of drugs (drugs foxglove, cytostatic drugs / substances that suppress cell division, antibiotics and others). Diet and other violations.
The drug has no effect on vomiting of vestibular origin (caused by motion sickness).
In the gastroenterological practice the drug is used in treatment of gastric ulcer and duodenal ulcer, gastritis, dyskinesia (violation of mobility) abdominal postoperative paresis (reducing the strength and / or range of motion) of the intestine, flatulence (gas accumulation) and other diseases.
The therapeutic effect is associated with increased tone of the stomach and intestines, the acceleration of gastric emptying and pyloric (narrowing of the stomach in the place of his move to the duodenum), the decrease hyperacid stasis (stopping the movement of food in the stomach due to acidification).
There is evidence of the effectiveness of metoclopramide in the treatment of dyspepsia (repeated vomiting, nausea) in heavy heart patients (myocardial infarction, heart failure) and vomiting during pregnancy.
The drug is also found use as a means to facilitate and improve radiological diagnostic of diseases of the stomach and small intestine.
There is evidence of the high efficiency of metoclopramide with migraines and the successful use of the drug in Tourette's syndrome (generalized tics - involuntary twitching of the face - in children).
How It Works?
Reglan is a procainamide derivative. Reglan is a dopamine receptor blocker. Reglan is a centrally-acting antiemetic effect and a motility promoting effect in gastric duodenum-small intestine area. Reglan synchronizes antral and duodenal contractions. In patients with gastroesophageal reflux increases Reglan muscle tone in cardiac sphincter, increases peristalsis in the lower esophagus and reduces the number of reflux occasions.
How It Is Taken?
Take a pill of Reglan by mouth; in severe cases, the drug is used parenterally (intramuscularly or intravenously).
Inside adults usually give 10mg (one tablet) three times a day (before meal). Tablets are swallowed without chewing, with some water.
Reglan has fewer side effects when taken after a meal.
Is It For Me?
Your doctor will determine if it is appropriate for you personally to use Reglan. However, here is a quick tip on what conditions can prevent you from Reglan therapy approval:Hypersensitivity to the active substance or to any of the excipients contained in the drug.
Gastrointestinal bleeding, mechanical obstruction or gastrointestinal perforation where stimulation of gastrointestinal motility constitutes a risk
Confirmed or suspected pheochromocytoma due to the risk of severe hypertensive episodes
Earlier tardive dyskinesia induced by neuroleptics or Reglan
Epilepsy (increased seizure frequency and intensity)
Combination with levodopa or dopamine agonists
Formerly known methemoglobinemia caused by Reglan or NADH-cytochrome b5 deficiency
Use in children younger than one year, because of increased risk of extrapyramidal disorders, is prohibited.
Any Drug Interactions or Incompatibilities?
Levodopa or dopaminergic agonists and Reglan have a mutual antagonistic effect. Combination to be avoided. Alcohol enhances the sedative effect of Reglan. Combination to be taken into account.
Because of the prokinetic effect of Reglan, absorption of certain drugs affected. Anticholinergics and morphine derivatives can both have a mutual antagonistic effect of Reglan on the gastrointestinal tract motility. The sedative effect of CNS depressants is reinforced by Reglan. Reglan can have an additive effect to other neuroleptics for extrapyramidal disorders.
The use of Reglan with serotonergic drugs such as SSRIs may increase the risk of serotonin syndrome.
Reglan may reduce the bioavailability of digoxin. Careful monitoring of plasma concentrations of digoxin is necessary.
Reglan increases the bioavailability of cyclosporin (Cmax by 46% and exposure by 22%). Careful monitoring of plasma concentrations of cyclosporin is necessary. The clinical consequence is uncertain.
Reglan exposure levels are increased during co-administration with strong inhibitors of CYP2D6, such as fluoxetine and paroxetine. Although the clinical significance is unclear, patients should be monitored for adverse reactions.
What Side Effects Should I Brace Myself For?
The drug is generally well tolerated. In rare cases, extrapyramidal disorder (disturbance of coordination of movements with a decrease in their size and jitter), typical of Parkinson's disease, can occur. The mechanism of these side effects plays apparently antagonistic role of metoclopramide on the dopamine receptors in the brain. To remove these effects caffeine is administered parenterally (via IV or IM injections).
Reglan is also known for being able to cause drowsiness, tinnitus, and dry mouth. To reduce these phenomena, it is designated to take the pills of Reglan sometimes after a meal.
Any Important Tips?
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