Ranitidine (Zantac) is an antiulcer agent that belongs to the group of antagonists of histamine H2 receptor. It selectively blocks the histamine H2-receptors of parietal cells of the gastric mucosa and inhibits the release of hydrochloric acid.
Ranitidine decreases total secretion, which leads to lower amounts of pepsin in the gastric contents. Antisecretory effect of Ranitidine creates favorable conditions for the healing of gastric ulcers and 12 duodenal ulcer. Ranitidine increases the protective factors in the tissues of the gastroduodenal zone: strengthens reparative processes, improves microcirculation, and fosters the secretion of mucous substances.
You can buy Ranitidine online at AWC Canadian Pharmacy:
Ranitidine belongs to the group of drugs called histamine (H2) blockers and works by reducing the production of hydrochloric acid in the stomach. Typically, gastric juice in such patients is highly acidic and may leak up into the esophagus causing heartburn and acid reflux. The acid inhibitory effect lasts up to 12 hours.
The acid production can be stimulated by smoking, alcohol, spicy food and stress. Certain drugs such as aspirin and other anti-inflammatory drugs for joint and muscle problems can also be the cause of heartburn and other stomach acid-related disorders.
The drug is used in the following conditions:
Gastric ulcer and duodenal ulcer in the acute stage;
Prevention of relapse of peptic ulcer disease;
Symptomatic ulcers (rapidly developing gastric and duodenal ulcers as a result of stress exposure, medication or other diseases of the internal organs);
Erosive esophagitis (inflammation of the esophagus with the violation of the integrity of its mucosa) and reflux esophagitis (inflammation of the esophagus due to throwing of gastric contents into the esophagus);
Zollinger-Ellison syndrome (a combination stomach ulcers and benign tumors of the pancreas);
Prevention of lesions of the upper gastrointestinal tract and in the postoperative period;
Prevention of gastric aspiration (getting gastric juice in the airways) in patients undergoing surgery under general anesthesia.
How It Works?
Ranitidine (Zantac), a chemically substituted amino-alkyl furan, is an H2-receptor antagonist, which competitively blocks the action of histamine H2-receptor, thereby inhibiting basal and stimulated gastric secretion, both in volume and in hydrochloric acid content. Through the reduction of gastric volume, Ranitidine also reduced the total pepsinogenic.
How It Is Taken?
Adults / adolescents (from 12 years):
Duodenal ulcer, benign gastric ulcer: 300mg / 2four hours, either 300mg at night or 150mg morning and evening. Treatment duration is normally four weeks. For those patients whose wounds have not healed completely after four weeks of treatment, the treatment should continue for a further four weeks. The dose may be increased to 300mg morning and evening for four weeks.
Prophylactic treatment of chronic recurrent duodenal ulcer: 150mg in the evening.
Reflux esophagitis: 150mg in the morning and evening, alternatively 300mg at night for four-eight weeks, but the dose and duration of treatment should be individualized according to disease severity. In severe cases, the dose can be increased up to 600mg in divided doses for up to 12 weeks. In maintenance recommended 150mg morning and evening.
Symptomatic gastroesophageal reflux disease: 150mg morning and evening for two-four weeks.
Zollinger-Ellison syndrome: 150mg three times daily, but the dose can be increased if necessary. Ranitidine doses up to 6g have been effectively prescribed.
The dose should be reduced in renal and / or hepatic function and in elderly patients.
Is It For Me?
Hypersensitivity to the active substance or to any of the excipients is a reason to abstain from Ranitidine therapy. Ranitidine should not be given to patients with a history of acute porphyria, pregnant and lactating women.
Any Drug Interactions or Incompatibilities?
Ranitidine has the potential to affect the absorption, metabolism or renal excretion of other drugs. Changes in pharmacokinetics may require dosage adjustment or discontinuation of the medicinal product concerned.
Interaction occurs through several mechanisms:
Changes in gastric pH
The bioavailability of certain drugs may be affected. This can result in increased absorption (e.g. triazolam, midazolam, glipizide) or decreased absorption (e.g., ketoconazole, atazanavir, delaviridine, gefitinib).
There is no evidence for interactions between ranitidine and amoxicillin. If antacids or high doses of sucralfate (2 mg) are administered with Ranitidine, the absorption of the latter is reduced. Ranitidine should be taken about two hours before these drugs.
Inhibition of the cytochrome P450-linked "mixed function" - oxygenase system
At therapeutic doses does not potentiate ranitidine drugs which are inactivated by this system, such as diazepam (CYP2C19), lidocaine and propranolol. Altered prothrombin times have been reported with coumarin anticoagulants (e.g., warfarin) when treatment where Ranitidine has begun. Because of narrow therapeutic window, close monitoring of increased or decreased prothrombin time at concurrent treatment with Ranitidine is recommended.
There are several case reports of increased plasma concentration of theophylline. Although the interaction has not been observed in several clinical studies it is not excluded that the interaction may occur in some individuals.
Increased plasma concentrations of phenytoin has also been reported.
Competitive interaction in renal tubules
Since Ranitidine is partially eliminated by cationic transporter (OCT) in the kidney, it can affect the clearance of other drugs eliminated by this route. High doses of Ranitidine (e.g. in the treatment of Zollinger-Ellison syndrome) may reduce the excretion of procainamide and N-acetyl procainamide resulting in increased plasma concentrations of these drugs.
The effect of alcohol may be enhanced with concomitant intake of Ranitidine.
What Side Effects Should I Brace Myself For?
Ranitidine is relatively well tolerated, side effects are less frequent than with cimetidine. Rarely observed Ranitidine side effects are: headache, dizziness, fatigue, skin rash, thrombocytopenia (decrease in the number of platelets in the blood), a slight increase in serum creatinine at the beginning of treatment; very rare - hair loss. In severely ill possible side effects are confusion, hallucinations (delirium, vision, acquiring the nature of reality).
Long-term use of high doses can lead to increased levels of prolactin (a hormone of the pituitary gland), gynecomastia (breast enlargement in men), amenorrhea (cessation of menstruation), impotence (sexual weakness), decreased libido (sexual desire), leukopenia (reduction in white blood cell count). There have been known several cases of hepatitis (inflammation of the liver).
Any Important Tips?
Remember that shopping for your pills responsibly is investing in your health. Do not buy from random retailers.
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Your purchase of Ranitidine at Canadian Pharmacy will include four men's health pills of your choice.
Heartburn and acid reflux can be caused by gastric acid entering the esophagus during bed rest, or heavy lifting. Heartburn and acid reflux can also occur with stomach ulcers, and in rare cases also the more serious diseases of the stomach or esophagus. One important measure that can provide relief from heartburn and acid reflux is to change your way of life. This may involve, inter alia: to reduce smoking, avoid coffee, alcohol, spicy food, late suppers and heavy lifting. You should try to get a regular, stress-free way of life. Sleeping with your head higher than the rest of your body during the night can also relieve symptoms. Another measure can be treated with prescription medication. If these steps do not help, consult a doctor. This is especially important if you have persistent or recurring discomfort, difficulty swallowing, or if your doctor has told you that you have reduced kidney function.
Ranitidine - contraindications, warnings and precautions
Safety and efficacy have not been established in neonates.
The plasma half-life is prolonged and plasma concentrations increase in renal impairment. The dose should be in the case of markedly impaired renal function at least halved. An appropriate dose for oral therapy is 150mg at night.
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