Metoclopramide is an anti-emetic (a medicine for nausea and vomiting). It contains a substance called metoclopramide. It acts on an area in the brain that prevents you from getting sick and throwing up.
You can buy Metoclopramide online at AWC Canadian Pharmacy:
for the prevention of delayed nausea and vomiting that may occur after chemotherapy
to prevent nausea and vomiting caused by radiation therapy
to treat nausea and vomiting, including nausea and vomiting that may occur in migraine. Metoclopramide can be taken with drugs against pain (taken by mouth) in migraine to get better effect of the painkiller.
Metoclopramide is also used in children (aged 1-18 years) if other treatments do not work or cannot be used for the prevention of delayed nausea and vomiting that may occur after chemotherapy.
How It Works?
Metoclopramide is a procainamide derivative. Metoclopramide is a dopamine receptor blocker. Metoclopramide is a centrally-acting antiemetic effect and a motility promoting effect in gastric duodenum-small intestine area. Metoclopramide synchronizes antral and duodenal contractions. In patients with gastroesophageal reflux increases Metoclopramide muscle tone in cardiac sphincter, increases peristalsis in the lower esophagus and reduces the number of reflux occasions.
How It Is Taken?
The recommended single dose is 0.1 to 0.15 mg / kg body weight, which may be repeated up to three times daily via oral administration. The maximum dose in 24 hours is 0.5 mg / kg body weight.
The maximum duration of treatment is 5 days for the prevention of delayed nausea and vomiting induced by chemotherapy.
Tablets are not suitable for use in children weighing less than 30 kg. Other pharmaceutical forms / strengths may be more appropriate for administration to this population.
Is It For Me?
Your doctor will determine if it is appropriate for you personally to use Metoclopramide. However, here is a quick tip on what conditions can prevent you from Metoclopramide therapy approval:
Hypersensitivity to the active substance or to any of the excipients contained in the drug.
Gastrointestinal bleeding, mechanical obstruction or gastrointestinal perforation where stimulation of gastrointestinal motility constitutes a risk
Confirmed or suspected pheochromocytoma due to the risk of severe hypertensive episodes
Earlier tardive dyskinesia induced by neuroleptics or metoclopramide
Epilepsy (increased seizure frequency and intensity)
Combination with levodopa or dopamine agonists
Formerly known methemoglobinemia caused by metoclopramide or NADH-cytochrome b5 deficiency
Use in children younger than one year, because of increased risk of extrapyramidal disorders, is prohibited.
Any Drug Interactions or Incompatibilities?
Levodopa or dopaminergic agonists and metoclopramide have a mutual antagonistic effect. Combination to be avoided. Alcohol enhances the sedative effect of metoclopramide. Combination to be taken into account.
Because of the prokinetic effect of Metoclopramide, absorption of certain drugs affected. Anticholinergics and morphine derivatives can both have a mutual antagonistic effect of metoclopramide on the gastrointestinal tract motility. The sedative effect of CNS depressants is reinforced by Metoclopramide. Metoclopramide can have an additive effect to other neuroleptics for extrapyramidal disorders.
The use of Metoclopramide with serotonergic drugs such as SSRIs may increase the risk of serotonin syndrome.
Metoclopramide may reduce the bioavailability of digoxin. Careful monitoring of plasma concentrations of digoxin is necessary.
Metoclopramide increases the bioavailability of cyclosporin (Cmax by 46% and exposure by 22%). Careful monitoring of plasma concentrations of cyclosporin is necessary. The clinical consequence is uncertain.
Metoclopramide exposure levels are increased during co-administration with strong inhibitors of CYP2D6, such as fluoxetine and paroxetine. Although the clinical significance is unclear, patients should be monitored for adverse reactions.
What Side Effects Should I Brace Myself For?
Methemoglobinemia, which can be related to NADH cytochrome b5 reductase deficiency, especially in neonates.
Cardiac arrest, which occurs just after injection, and may be due to a bradycardia; atrioventricular block, sinus arrest especially when administered intravenously, ECG QT prolongation, increase in blood pressure in patients with or without pheochromocytomas.
Extrapyramidal disorder (especially in children and young people and / or when the recommended dose is exceeded, even after administration of a single dose of the drug), parkinsonism, akathisia
Dystonia, dyskinesia, reduced consciousness
Seizures especially in patients with epilepsy
Any Important Tips?
Remember that shopping for your pills responsibly is investing in your health. Do not buy from random retailers.
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Your purchase of Metoclopramide at Canadian Pharmacy will include four men's health pills of your choice.
Metoclopramide - contraindications, warnings and precautions
Extrapyramidal disorders may occur especially in children and young people and / or when high doses are used. These reactions usually occur early in treatment and can occur after a single administration. Metoclopramide should be discontinued immediately at the extrapyramidal symptoms. These effects are in general fully reversible after discontinuation of treatment but may require symptomatic treatment.
To avoid overdose, the time interval of 6 hours between each administration should be respected, even if the dose cannot be maintained (e.g. vomiting or diarrhea).
Prolonged treatment with metoclopramide can cause tardive dyskinesia which may be potentially irreversible, especially in the elderly. Treatment should not exceed 3 months due the risk of tardive dyskinesia. Treatment must be discontinued if clinical signs of tardive dyskinesia appear.
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