Before you buy Advair Discus online
What It Does?
Advair Discus does not treat acute asthma attacks when you feel breathless. Another drug is used to treat acute attacks.
Fluticasone propionate available in Advair Discus may also be approved to treat other diseases not mentioned in this piece. Ask your doctor, pharmacist or other healthcare professional if you have further questions and always follow their instructions.
How It Works?
Fluticasone propionate is a glucocorticoid with anti-inflammatory effects. Treatment with inhaled fluticasone propionate at recommended doses has a potent glucocorticoid anti-inflammatory effect in the lungs which leads to both asthma symptoms and exacerbations is reduced, with a lower incidence and severity of side effects than those seen when corticosteroids are administered systematically. Treatment with fluticasone propionate is prophylactic. The full effect is achieved after 4-7 days of treatment. The plurality of particles are less than 5 microns.
How It Is Taken?
Advair Discus is intended for oral inhalation.
Patients should be made aware that treatment with Advair Discus is prevention and that it should be taken regularly even when asymptomatic.
If patients find that the effect of short-acting bronchodilator treatment becomes less or the need for more inhalations than usual, medical attention.
The dose should be titrated until symptom control is achieved or reduced to the lowest effective dose, depending on individual response. When control of symptoms is maintained with the lowest strength of Advair Discus (125 micrograms / dose) the next step may include a change to another inhaled fluticasone with lower strength (50 micrograms / dose). Therapeutic effect occurs within 4-7 days of treatment.
Prescribers should be aware that fluticasone propionate is as effective as other inhaled steroids at approximately half the daily dose expressed in micrograms. For example, equivalent to 100 micrograms of fluticasone propionate is approximately 200 micrograms of beclomethasone dipropionate (CFC containing) or budesonide.
Is It For Me?
Do not use Advair Discus if you are allergic to fluticasone propionate or any of the other ingredients in this medicine. The medicine is not intended for the treatment of acute instances of asthma.
Any Drug Interactions or Incompatibilities?
Under normal circumstances, only low plasma concentrations of inhaled fluticasone propionate are achieved because of extensive first pass metabolism and high systemic clearance by cytochrome P450 3A4 in the gut and liver. Clinically significant drug interactions via fluticasone propionate by fluticasone propionate are unlikely.
In an interaction study with healthy volunteers who received fluticasone propionate, appeared ritonavir (a highly potent cytochrome P450 3A4 inhibitor) 100 mg bid increase plasma concentrations of fluticasone propionate several hundred times, which in turn reduced cortisol serum concentration significantly. Information about this interaction is lacking for inhaled fluticasone propionate, but a marked increase in plasma levels of fluticasone propionate expected. Cases of Cushing's syndrome and adrenal suppression has been reported. The combination should be avoided unless the benefit outweighs the increased risk of systemic glucocorticoid side-effects.
In a small study in healthy volunteers, the slightly less potent cytochrome P450 3A4 inhibitor ketoconazole increased the exposure of fluticasone propionate 150% after a single inhalation. This resulted in a greater reduction of plasma cortisol as compared with fluticasone propionate alone. Concomitant treatment with other potent CYP3A inhibitors, such as itraconazole, klaritomycin, telithromycin, atazanavir, indinavir, nelfinavir and saquinavir, are also expected to increase the systemic fluticasone propionate exposure and the risk of systemic side effects. Caution is recommended and long-term treatment with such drugs should be avoided if possible.
What Side Effects Should I Brace Myself For?
Infections and infestations
Candidiasis of the mouth and throat
Hypersensitivity reactions in the form of:
Angioedema (mainly facial and oropharyngeal edema)
Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, decrease in bone mineral density, cataract, glaucoma
Anxiety, sleep disorders, behavioral problems including hyperactivity and irritability (predominantly in children)
Depression, aggression (mainly in children
Respiratory, thoracic and mediastinal disorders
Hoarseness / dysphonia
Any Important Tips?
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