ed analogues

Canadian Viagra And its Analogues Against ED

29 June of 2014

Erectile dysfunction, impotence, is a medical condition that affects millions of men worldwide. For some men, so the problems are mild – they have occasional problems getting or maintaining an erection. For other men, the situation is more serious and the problems with getting an erection happens often or always. In most cases, however impotence treatable.

There are many men who have Erectile Dysfunction and everyone experiences problems in different ways, it may for example mean that:

  • You cannot get an erection at all,
  • You get an erection, but it is not hard enough for penetration,
  • You get an erection but cannot maintain it until the sexual activity is over.

In order to get the treatment you need, you need to understand your condition.

Oral administration is now first choice in the treatment of impotence. Smooth muscle relaxation in the corpus cavernosum and the supplying blood vessels mediated by nitric oxide increases the amount of cGMP in the tissues. Normally, cGMP is broken down by the enzyme phosphodiesterase type 5. Large studies have shown that up to 80% of patients with impotence respond well to drugs that inhibit phosphodiesterase type 5 (PDE5 -I).

Sildenafil in Canada (Viagra) inhibits phosphodiesterase V and therefore strengthen erections. Cialis (tadalafil) and Levitra (vardenafil) has similar mechanism of action as Viagra, but they differ somewhat in terms of pharmacodynamics.

Canadian Pharmacy Cialis effect lasts for about 36 hours, but reaches maximum power after about 2 hours. Cialis is not affected by concomitant food intake.

Viagra and Levitra have maximum effect after 30 – 60 minutes with a duration up to 12 hours. The absorption is affected by co-administration of a high fat meal.

Some factors that may affect which drugs the patient preference are: frequency of sexual activity (high frequency suggests Cialis because of long duration), Co-occurrence of CVD or ongoing antihypertensive treatment (advantage for Viagra or Levitra for short duration). For those patients where Cialis Canada if necessary been effective, available today Cialis is used continuously in the form of 5 mg daily.

Drugs that inhibit phosphodiesterase type 5 has a vasodilatory effect and one should exercise caution when treating patients with heart disease. Light to moderate angina pectoris is not a contraindication, but it’s taken with nitrates is contraindicated. Viagra or Levitra can hence be preferable compared to Cialis, because of its shorter half-life. Many patients with erectile dysfunction also bothered by LUTS often treated with alpha blockade which often have a blood pressure lowering effect. Before PDE5 one prescribed to these patients, hypotension including orthostatism excluded. Alpha blockers are suitable in these cases, the short half-life (alfuzosin). Doxazocin should not be administered with Cialis. PDE5 has been shown in studies to give symptomatic relief even in LUTS (lower urinary tract symptoms), so this indication may possibly be relevant in the future.

There is no evidence to suggest that patients on Viagra, Cialis or Levitra have greater risk of sudden cardiac death during intercourse.

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